The Futurity Trophy will become the first Group One race in Britain run on an all-weather surface with the meeting moved to Newcastle after being washed out.
The final Group One race of the season, the one-mile (1600m) event for two-year-olds was scheduled to be run at Doncaster on Saturday.
Doncaster was waterlogged and the meeting will now move to the Tapeta track at Newcastle on Friday evening.
Original entries will stand but the race has been re-opened for new contenders.
Irish trainer Aidan O'Brien had five of the six youngsters scheduled to run in the Trophy with their sole opponent Kameko from Andrew Balding's stable.
"The straight mile at Newcastle is a fantastic track, as seen by the quality of young horses that have run here in the last few years, so we cannot wait for Friday and to be associated with a race of the highest quality at our home racecourse," John Dance, of sponsor Vertem Asset Management, said.
Both Doncaster and Newcastle are owned by Arena Racing Company with chief executive Martin Cruddace saying Newcastle was a great alternative.
"I am delighted we have been able to move so quickly to rearrange the race, at its original prize money levels, to Newcastle on Friday evening," he said.
"We hope all racing fans in the North East will embrace the fixture and come along to enjoy Britain's first ever Group One race run on an artificial surface.
"Our Tapeta track at Newcastle is world class, and I am sure the track will do the famous race proud."
Racing at Newbury was also called off because of the weather on Saturday, and that card's feature Group Three Horris Hill Stakes will now be run at Newmarket on Saturday.