Promising three-year-old Glenfiddich is out of the autumn carnival after suffering a career-threatening leg injury.

Trainer Peter Moody confirmed the news on twitter this week and said connections would weigh up whether to retire the valuable son of Fastnet Rock, or press ahead with a rehabilitation program.

"Disappointed to announce our three-year-old colt Glenfiddich will miss autumn carnival due to an injury sustained to his off foreleg. Owners will decide over weekend regarding rehab or retirement," Moody said.

Group One placed in the Champagne Stakes as a two-year-old, Glenfiddich won the Stutt Stakes in the spring and was being touted as a Caulfield Guineas and Cox Plate contender before a throat issue derailed his program.

He has been taken out of the nominations for the All-Star Mile, as has dual stakes winner Ain'tnodeeldun, who will miss the autumn after suffering a suspected pelvic injury.

Voting for the $5 million All-Star Mile officially opened to the general public on Friday.

Of the 81 nominated horses, the 10 most popular will earn a spot in the March 13 race, alongside five wildcard runners.

The entries include 23 Group One winners headed by Verry Elleegant, Sir Dragonet, Melody Belle and three-year-old Ole Kirk with voting to close on February 14.