A couple of road trips this year have helped Famous Seamus toughen up and trainer Noel Mayfield-Smith is certain he is on the way to fulfilling his destiny.

The Hawkesbury-based Mayfield-Smith makes no secret of his opinion Famous Seamus is up there with Landsighting, winner of the 2000 Stradbroke Handicap, as the best horse he has trained.

Famous Seamus will hit the highway again this week to run in the Group Three George Moore Stakes (1200m) at Doomben on Saturday.

His latest campaign has reaped a successful defence of the Listed Tatt's Lightning Stakes in October and a last-start Group Three third behind Lankan Rupee and Hot Snitzel in the Kevin Heffernan Stakes at Caulfield two weeks ago.

"He didn't handle the track at all so it was a great run," Mayfield-Smith said.

"Tim Clark is usually really conservative but he got off and was glowing in his opinion of him, so much so he is going to Doomben to ride him.

"The trip to Brisbane earlier this year really helped the horse. He has manned up a bit and I don't have the same worries about travelling him that I used to."

The winner of the Prime Minister's Cup in May, Famous Seamus was found to have the thumps after his unplaced run in the BTC Sprint and ran wide when again unplaced in the Stradbroke.

Queensland's premier sprint is again on the agenda but Mayfield-Smith will also look at the weight-for-age Doomben 10,000 in May as a Group One goal.

Mayfield-Smith said he would keep Famous Seamus ticking over at home between races rather than send him away for a spell.

"He is a horse who enjoys stable life so I'll give him a couple of weeks off every now and then and keep it at that," he said.

Famous Seamus was one of 24 entries taken on Monday for the Doomben feature along with 2009 Golden Slipper winner Phelan Ready and his Jason McLachlan-trained stablemate Facile Tigre who has been placed in the past two Oakleigh Plates.