German colt Sea The Moon has been ruled out of the Prix de l'Arc de Triomphe with injury.
Quickly promoted to the nation's star horse after his startling victory in the German Derby, Markus Klug's representative met with a surprise defeat when second to Ivanhowe in last weekend's Grosser Preis Von Baden.
Owners representative Niko Lafrentz told the German website GaloppOnline that Sea The Moon would have to be treated for an injury and would not run again this year.
He said it was hoped he would return for another season before retiring to stud.
This has caused a small change in the market, with Treve shortened to 7-2 favourite from 4-1 with William Hill, and Avenir Certain into 7-1 from 8-1.