His Group One winner Kirramosa is convalescing and the next best stayer in John Sargent's stable has joined her in sympathy.
But the Randwick trainer is confident he still has enough depth on his books to save his spring carnival from being a complete write-off.
And his fortunes could improve as soon as Wednesday on his home track when he runs last-start winner Mr One Eleven with 60kg in the James Boag's Premium Handicap (2500m).
Kirramosa is sidelined with a hamstring issue, an injury that explains her below-par run in the Caulfield Stakes.
"When she went across the line in the Caulfield Stakes she ran out to the right and it was obvious she did something during the running," Sargent said.
Sargent's Queensland Cup winner Iggi Pop is also sidelined after coming out of the Group One Metropolitan with a tendon strain.
It's a double blow for the ex-New Zealand trainer who is trying to establish himself in Australia but the spring is retrievable with a horse such as Neena Rock and, to a lesser extent, Mr One Eleven.
Angst Stakes winner Neena Rock is a definite Melbourne Cup carnival starter, giving Sargent a Group One presence in the Myer Classic and maiden filly Thunder Lady continues on a VRC Oaks campaign despite a last-start Newcastle defeat.
But first Mr One Eleven will be out to confirm his promise as a stayer at Randwick.
Sargent thought enough of Mr One Eleven as an autumn three-year-old to run him in the Rosehill Guineas.
"I was aiming him for the (ATC Australian) Derby but his run was a bit weak so we pulled the pin," Sargent said.
Mr One Eleven is by Shaft, a son of Flying Spur who never ran beyond 1200m in a career cut short during his three-year-old term.
"He has obviously thrown to dam side," Sargent said.
"This time in we've got him to where he should be and he'll be better with time as well.
"It's a big weight he's carrying but he's as good as I can get him and he should run very well again," Sargent said.