Golden Horn headlines a strong team from Britain and Ireland entered for the Breeders' Cup meeting at Keeneland in Kentucky.
The John Gosden-trained colt has won the Derby, Eclipse, Irish Champion Stakes and Prix de l'Arc de Triomphe this season and will bid to end his racing career with victory in the Breeders' Cup Turf on October 31.
"The plan is for him to head out on Saturday, all being well," Gosden said.
"He has held his condition extremely well. He put the weight back on to what he was before the Arc five days after the race."
Roger Charlton's impressive Royal Ascot winner Time Test is primed for the Breeders' Cup Mile, having pleased in a recent racecourse gallop under Ryan Moore at Wolverhampton.
Current champion Karakontie is back to defend his crown for soon-to-retire trainer Jonathan Pease and the Niarchos family.
Dual 2000 Guineas winner Gleneagles has been entered in the Breeders' Cup Classic on dirt, and is one of nine possible runners at the meeting from Ireland.
Gleneagles' Aidan O'Brien-trained stablemate Found is entered for the Breeders' Cup Turf.
O'Brien has War Envoy in the mile races on turf and dirt, with Waterloo Bridge, Shogun, Hit It A Bomb and Alice Springs in contention for the two-year-old contests.
David Wachman could run star filly Legatissimo, who is likely to start favourite for the Filly and Mare Turf.