St Nicholas Abbey faces a critical few weeks as the multiple Group One winner continues his fight to fully recover from a fractured pastern and ensuing complications.
Aidan O'Brien's star had to be retired after suffering the leg injury during a routine work-out in July.
Just two days after he underwent a major leg operation, the six-year-old had to have emergency surgery for colic.
He had a further setback in August when it was discovered a steel weight-bearing pin in a cannon bone had broken, and last month was hit by a serious blow relating to "mild laminitic changes in the left fore".
The latest update from owners Coolmore says the horse is still struggling with laminitis.
"St Nicholas Abbey is struggling to overcome the laminitis in his left front foot, this is indeed life threatening and is the single biggest complication he has faced since his initial lifesaving surgery," Coolmore said.
"The worry is that if the condition progresses and further sinking of the pedal bone takes place it may prolapse through the sole of his foot.
"In spite of this St Nicholas Abbey is very comfortable. His appetite and demeanour remain incredibly good.
"His intensive veterinary treatment continues and includes maggot therapy for the slight discharge at the toe of the laminitic foot and a daily session on a vibrating plate.
"The next few weeks are critical for St Nicholas Abbey - we are just hoping that he can turn the corner."