Former Godolphin racing manager Simon Crisford is to set up his own training business, subject to approval from the British Horseracing Authority.
Crisford, who worked for Sheikh Mohammed's operation since its inception in 1994, left his position to take up the role of global racing advisor to the Maktoum family after a number of changes to the organisation in February.
He is to start his new career by renting out part of Clive Brittain's stable at Newmarket.
"It is something I have always wanted to do and I am delighted to have the opportunity to realise that ambition now," Crisford said.
Crisford will continue his consultancy work as international racing advisor to the Maktoum family and their associates.
The 52-year-old previously worked as assistant trainer to John Dunlop and Sir Mark Prescott and also has close associations with Saeed bin Suroor and Andre Fabre, two of Godolphin's main trainers.
"I have been around top class horses for the best part of 30 years, having also had the privilege of working closely with Saeed bin Suroor, Andre Fabre and John Gosden," Crisford said.
"But most of all I have learned so much about horses from Sheikh Mohammed. Without doubt he has been the greatest influence on my career.
"I will be operating as a public trainer but I also hope that the Maktoum family might consider supporting me."
Crisford's role changed at Godolphin on the back of an internal investigation by Lord Stevens into former trainer Mahmood Al Zarooni, who was warned off for eight years.
The investigation concluded Al Zarooni acted alone in giving 11 horses in his stables banned substances, but that "stronger management, clearer accountability and better internal communication within the equestrian organisation" were needed.
As a result, the role of racing manager within the organisation no longer existed.