Warren Place, the historic Newmarket training base of the late Sir Henry Cecil, is to be sold and his widow Lady Cecil will retire from training at the end of the season.
Cecil died in 2013 with Lady Cecil subsequently taking out a licence to train in her own right.
Sheikh Mohammed is believed to be among the interested parties for the famous property.
"Training, for me, has always been about working with the horses and the team here at Warren Place. That has been a major factor in why I have continued since Henry died two years ago," Lady Cecil said in a statement.
"Therefore, I confirm that at the end of the Flat season, I will stop training. Until then, the team and I will continue to work hard to achieve as much as we can with the horses."
Lady Cecil enjoyed success last season with Noble Mission, a brother to the stable's champion Frankel.
Noble Mission, who now stands at stud in the United States, won three Group Ones races culminating in an emotional success in the Champion Stakes at Ascot.
A spokesman for Sheikh Mohammed declined to comment on speculation the Dubai ruler was to buy Warren Place.