Golden Horn is odds-on to keep his unbeaten record intact when he runs in the King George VI And Queen Elizabeth Stakes.
The John Gosden-trained three-year-old is the headline act among 11 horses confirmed for Ascot's midsummer showpiece on Saturday following his stunning display in the Epsom Derby and Eclipse Stakes at Sandown.
He sits at the top of the international ratings on a mark of 130 in the latest world rankings.
The last horse to complete the Derby-King George double was Galileo in 2001.
Sir Michael Stoute has won the King George a record-equalling five times and has strengthened his hand for this year's race by paying the late entry for Snow Sky, winner of the Hardwicke Stakes at Royal Ascot.
Stoute is also set to saddle last year's runner-up Telescope, who needs to bounce back from a disappointing run behind his stable companion at the Royal meeting.
Golden Horn is one of three possible runners for Gosden, with Hardwicke runner-up Eagle Top and Romsdal also in contention.